Pushing the Sensitivity Limits in Proteomics

Founded in 2023 as a spin-out from Northeastern University’s Ivanov Lab, MixedLCmediA is driven by the belief that the smallest samples often hold the biggest secrets.

Novel PLOT Chromatography Column-Based Platform to Increase Sensitivity of Mass Spectrometry Analysis

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PATENT PENDING
Our team combines deep expertise in ultra-low flow liquid chromatography, mass spectrometry, and micro-scale analysis. Together, we have developed a plug-and-play, cell phone-sized platform that increases signal-to-noise, profiling depth, and sensitivity in molecular analysis—unlocking new frontiers in clinical, academic, and translational research.

With a patent application filed and early collaborations underway with leading institutions as beta-testers, we are building a product that meets the demands of modern technology to address challenging questions in biology.
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Our PLOT Column Format Increases Signal-to-Noise, Depth, and Sensitivity of Proteomic Profiling

Our proprietary technology increases protein identification compared to conventional methods. Early-stage prototype testing confirms both feasibility and scalability, with a robust commercialization path underway.
Designed for Limited Samples
Improved Molecular Profiling Sensitivity
Enhanced Proteomic Characterization Results

Product Vision

The MVP consists of a trap column, a PLOT (analytical) column, and an ESI emitter connected via zero-dead-volume fittings. All of these are enclosed in a case to prevent damage during handling and use.
PLOT Column Optimization

Starting Point

Our initial step was to optimize the PLOT column to prevent clogging and result in better separation performance.
Prototype Build & Testing

Current Stage

We built a cell phone sized plug-and-play product for a chromatography column that performs liquid chromatography and mass spectrometry.
Pilot Product

Next Steps

Next, we plan to pilot the product as a robust, reliable, thoroughly evaluated, and ready-to-disseminate platform.
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We are Helping to Advance Health with Clinical Trials and Vaccines Development.

We believe in harnessing science for human good, so we work day and night, around the world, to deliver answers for health questions.
World Class Diagnostics
We have developed some of the world's most advanced testing capabilities to help improve health and lives.
Leader in Drug Development
With the support of our diagnostics capabilities to deliver drug trials that are both reliable and rigorous,
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